[Distribution of haptoglobin types and their significance in biochemical and immunologic indicators in persons exposed to low radiation doses]. / Raspredelenie tipov gaptoglobina i ikh znachenie v izmeneniiakh biokhimicheskikh i immunologicheskikh pokazatelei u liudei, obluchennykh v malykh dozakh.

ABSTRACT

Haptoglobin (Hp) polymorphism and its significance for changes in biochemical and immunological parameters was analyzed in personnel of a nuclear plant receiving doses of external and internal irradiation close to maximum permissible levels. The distribution of Hp types and frequencies of alleles Hp in the group of probands asa a whole (1-1 - 14.1%; 2-1 - 49.2%; and 2-2 - 36.7%) and in probands subjected to different types and doses of irradiation (1-1, 13.6 - 16.0%; 2-1, 47.8 - 50.5%; and 2-235.8 - 38.2%) did not differ from those expected or from corresponding parameters of the control group and population. An increase in the frequency of allele Hp was observed for persons over 60 years of age. It was found that the levels of uric acid, the activities of acid phosphatase, lactate dehydrogenase, alkaline phosphatase and its isozymes, and the content of certain lymphocyte classes and immune complexes are initially higher in carriers of Hp type 1-1. In these probands, changes in certain parameters related to irradiation were observed less frequently. In some cases, opposite changes in immunological parameters were observed in persons with different Hp types after internal irradiation.