Influence of endothelium on responses of isolated dog coronary artery to beta-adrenoceptor agonists.
Zhongguo Yao Li Xue Bao
; 16(4): 357-60, 1995 Jul.
Article
em En
| MEDLINE
| ID: mdl-7668110
ABSTRACT
AIM:
To study the role of the endothelium in mediating the response of the coronary arteries to adrenoceptor agonists.METHODS:
Endothelium intact and denuded dog epicardial coronary artery rings were used. The contractile responses were recorded on forcetransducer and a pen recorder.RESULTS:
In all ring segments, norepinephrine (NE) and isoproterenol (Iso) produced concentration-dependent relaxation in the presence and absence of phentolamine. Endothelium-removal decreased this relaxation and depressed the maximal response. Inhibition of nitric oxide synthesis by N omega-nitro-L-arginine-methyl ester induced the same influences as endothelium-removal.CONCLUSION:
beta-adrenoceptor agonists produce relaxation of dog coronary artery by both endothelium-dependent and independent mechanisms, endothelium-dependent relaxation induced by beta-adrenoceptor agonists is mediated by nitric oxide.
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Base de dados:
MEDLINE
Assunto principal:
Vasodilatação
/
Endotélio Vascular
/
Agonistas Adrenérgicos beta
/
Vasos Coronários
Idioma:
En
Ano de publicação:
1995
Tipo de documento:
Article