The multidrug resistance (mdr1) gene product functions as an ATP channel.
Proc Natl Acad Sci U S A
; 90(1): 312-6, 1993 Jan 01.
Article
em En
| MEDLINE
| ID: mdl-7678345
ABSTRACT
The multidrug resistance (mdr1) gene product, P-glycoprotein, is responsible for the ATP-dependent extrusion of a variety of compounds, including chemotherapeutic drugs, from cells. The data presented here show that cells with increased levels of the P-glycoprotein release ATP to the medium in proportion to the concentration of the protein in their plasma membrane. Furthermore, measurements of whole-cell and single-channel currents with patch-clamp electrodes indicate that the P-glycoprotein serves as an ATP-conducting channel in the plasma membrane. These findings suggest an unusual role for the P-glycoprotein.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Resistência a Medicamentos
/
Glicoproteínas de Membrana
/
Trifosfato de Adenosina
/
Canais Iônicos
Idioma:
En
Ano de publicação:
1993
Tipo de documento:
Article