Zinc induces hyperexcitability in the hippocampus.
Neuroreport
; 5(18): 2669-72, 1994 Dec 20.
Article
em En
| MEDLINE
| ID: mdl-7696629
ABSTRACT
The effects of zinc on neuronal excitability in rodent hippocampal slices were examined. In a paired-pulse protocol, the second population spike increased appreciably in the presence of zinc, whereas the first spike and the size of both population excitatory post-synaptic potentials remained unaffected. Changes in the second population spike produced by zinc were most pronounced when the afferents were stimulated with paired-pulses separated by 8-40 ms. The magnitude of altered excitability increased with the concentration of zinc in the perfusate. A long exposure to zinc in physiological concentration caused an epileptiform discharge followed by a period of depression. The effects of zinc could be mimicked with 1-3 microM bicuculline. We conclude that the integrity of the hippocampal inhibitory system is particularly vulnerable to zinc.
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Base de dados:
MEDLINE
Assunto principal:
Zinco
/
Hipocampo
Idioma:
En
Ano de publicação:
1994
Tipo de documento:
Article