Tumour necrosis factor, interleukin-6 and C-reactive protein in patients with louse-borne relapsing fever in Ethiopia.
Ann Trop Med Parasitol
; 89(1): 49-54, 1995 Feb.
Article
em En
| MEDLINE
| ID: mdl-7741594
ABSTRACT
The serum concentrations of tumour necrosis factor (TNF), interleukin-6 (IL-6) and C-reactive protein (CRP) were studied in 25 patients with louse-borne relapsing fever, to evaluate their association with the level of bacteraemia, anti-borrelia chemotherapy and the presence of a Jarish-Herxheimer reaction (JHR). Although there was an association between the level of bacteraemia and the development of JHR and complications during treatment, TNF, IL-6 and CRP concentrations were not associated with the JHR. TNF concentrations increased after the administration of antibiotics and remained high for 24 h. IL-6 was elevated on admission but soon decreased. CRP was high on admission and remained so throughout the illness. The observed elevations in TNF, IL-6 and CRP may be associated more with the administration of antibiotics than with the presence of a JHR.
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Base de dados:
MEDLINE
Assunto principal:
Febre Recorrente
/
Proteína C-Reativa
/
Interleucina-6
/
Fator de Necrose Tumoral alfa
Idioma:
En
Ano de publicação:
1995
Tipo de documento:
Article