NGF-dependent neurotrophic-like effects of AF102B, an M1 muscarinic agonist, in PC12M1 cells.
Neuroreport
; 6(3): 485-8, 1995 Feb 15.
Article
em En
| MEDLINE
| ID: mdl-7766849
ABSTRACT
The non-selective muscarinic agonist oxotremorine induces atropine-sensitive neurite outgrowth in PC12 cells stably transfected with m1 muscarinic receptors. In contrast, AF102B, an M1-selective muscarinic agonist, mediated minimal neurite outgrowth in these cells. In the presence of nerve growth factor (NGF) however, it induced atropine-sensitive neurite outgrowth in almost half the cell population. AF102B mediated phosphoinositide hydrolysis, but unlike carbachol, it did not stimulate cyclic AMP accumulation in these cells. These signals were not affected by NGF, indicating that they were not directly responsible for the cholinergic neurotrophic-like response. Our observations suggest that AF102B may improve neuronal responsiveness to neurotrophic factors, and thus may provide another beneficial aspect for treating Alzheimer's disease.
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Base de dados:
MEDLINE
Assunto principal:
Quinuclidinas
/
Tiofenos
/
Fatores de Crescimento Neural
Idioma:
En
Ano de publicação:
1995
Tipo de documento:
Article