[Study of mechanism of selective head cooling-dehydration combined therapy for brain resuscitation: effect on function of brain cellular membrane].
Zhonghua Wai Ke Za Zhi
; 32(11): 688-91, 1994 Nov.
Article
em Zh
| MEDLINE
| ID: mdl-7774412
ABSTRACT
We induced cerebral complete ischemia (CCI) by "four-vessel" model. The changes of Na+,K(+)-ATPase, Ca2+, Mg(2+)-ATPase, phospholipase A2 (PLA2), total phospholipids on brain cellular membrane (BCM) at 30, 180, 360 min of reperfusion following 30 min CCI were observed. The effects of selective head cooling (SHC, 28C, surface cooling method), mannitol dehydration (MD), and selective head cooling-dehydration combined therapy (SHCDCT) on these changes were also investigated. Compared with non-ischemic, during reperfusion activities of Na+, K(+)-ATPase, Ca2+, Mg(2+)-ATPase decreased while PLA2 increased (P < 0.001), phospholipids decreased at 180 and 360 min of reperfusion (P < 0.01). SHC and SHCDCT blocked all above changes, MD had no effect. These results suggest that SHCDCT after starting reperfusion do promote recruitment of BCM function by blockade of the successive reperfusion damage on BCM.
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Base de dados:
MEDLINE
Assunto principal:
Fosfolipases A
/
Traumatismo por Reperfusão
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Isquemia Encefálica
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ATPase de Ca(2/) e Mg(2/)
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ATPase Trocadora de Sódio-Potássio
Idioma:
Zh
Ano de publicação:
1994
Tipo de documento:
Article