[Mechanism of scavenging effects of (-)-epigallocatechin gallate on active oxygen free radicals].
Zhongguo Yao Li Xue Bao
; 15(4): 350-3, 1994 Jul.
Article
em Zh
| MEDLINE
| ID: mdl-7801780
ABSTRACT
The concentration of 50% scavenging ratio (SC50) and the scavenging rate constants (k) and stiochiometric factor (n) were determined when (-)-epigallocatechin gallate [(-)-EGCG] scavenging superoxide anion free radical (O2.-) and hydroxyl radical (.OH). The mechanism of scavenging active free radicals of (-)-EGCG and the promotion of (-)-EGCG free radical and its structure were analyzed in vitro. Our results suggest that the centers of scavenging reaction of (-)-EGCG are B, D, and A cycles, and each (-)-EGCG traps six O2.- or .OH. It is in accord with the value of stiochiometric factor n = 6.
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Base de dados:
MEDLINE
Assunto principal:
Catequina
/
Sequestradores de Radicais Livres
Idioma:
Zh
Ano de publicação:
1994
Tipo de documento:
Article