Cerebrospinal fluid analysis in HIV-1-infected children: immunological and virological findings before and after AZT therapy.
Acta Paediatr
; 83(10): 1038-42, 1994 Oct.
Article
em En
| MEDLINE
| ID: mdl-7841699
ABSTRACT
Immunological and viral studies were conducted on cerebrospinal fluid from 31 HIV-1-infected children, of whom 23 were neurologically asymptomatic and 8 had progressive encephalopathy. After AZT treatment, a second cerebrospinal fluid specimen was obtained from 15 children, 11 of whom were neurologically asymptomatic and 4 had progressive encephalopathy. Virus isolation and p24Ag detection were more frequent in children with progressive encephalopathy than in asymptomatic children (66% versus 12%) and were inversely correlated with intrathecal HIV-1-antibody detection (anti-gag AB 25% versus 70%). High concentrations of interleukin-1 beta (IL-1 beta) and IL-6 were found in children with progressive encephalopathy (50% and 37%, respectively), but low levels were also detected in some asymptomatic children (13% and 9%, respectively). Tumour necrosis factor-alpha (TNF alpha) was not found. AZT treatment induced disappearance of p24Ag in cerebrospinal fluid, as well as a marked reduction in cytokine levels. Cytokine determination may be useful in monitoring AZT treatment in children with progressive encephalopathy.
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Base de dados:
MEDLINE
Assunto principal:
Zidovudina
/
Infecções por HIV
/
HIV-1
Idioma:
En
Ano de publicação:
1994
Tipo de documento:
Article