[Studies on reproductive toxicity induced by enriched uranium].

ABSTRACT

Reproductive toxicity induced by body contamination with enriched uranium (235UO2F2) in different levels was studied. Results showed abnormalities dominated with bicaps and non-hock sperms could be induced by 235UO2F2. Chromosome aberration in spermatogonia induced by 235UO2F2 was dominated with chromosome breakage, and caused chromosome fragment, translocation, polyvalent in primary spermatocyte and DNA strand breakage in sperm. The quantity of sperm DNA strand breakage increased with the raise of intake of 235UO2F2. It was noted that enriched uranium could damage genetic materials in rats and cause dominant lethality and skeletal abnormalities in fetal rats. Incidence (B) of the induced skeletal abnormalities correlated positively to the injected dose (I) of 235UO2F2 into their testes with a regression equation of B = 28.84 + 0.86I.