Localization of the bronchodilator effect induced by type A natriuretic peptide in asthmatic subjects.
Clin Investig
; 72(10): 772-4, 1994 Oct.
Article
em En
| MEDLINE
| ID: mdl-7865980
ABSTRACT
Type A natriuretic peptide (CDD/ANP-99-126) in its circulating form was analyzed with respect to the localization of its bronchodilating effects in asthmatic subjects in vivo. The intravenous infusion of 5.7, 11.4, and 17.1 pmol kg-1 min-1 CDD/ANP-99-126 caused a significant bronchodilation of both central and peripheral airways. While the localization of the bronchodilating effects was similar to beta 2-agonists, an improvement in lung function parameters comparable to these substances was not observed. But other members of the natriuretic peptide family may reveal a stronger bronchodilating potency.
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Base de dados:
MEDLINE
Assunto principal:
Fragmentos de Peptídeos
/
Asma
/
Broncodilatadores
/
Fator Natriurético Atrial
Idioma:
En
Ano de publicação:
1994
Tipo de documento:
Article