Evidence against the existence of the purported Saccharomyces cerevisiae PKC2 gene.
Curr Biol
; 4(11): 990-5, 1994 Nov 01.
Article
em En
| MEDLINE
| ID: mdl-7874498
ABSTRACT
BACKGROUND:
The existence of a Saccharomyces cerevisiae gene encoding a novel isoform of protein kinase C was reported recently in this journal.RESULTS:
We demonstrate here that, firstly, the purported PKC2 gene does not reside at the chromosomal location to which it was assigned; secondly, it does not exist as a contiguous sequence in the S. cerevisiae genome; thirdly, some of its reported sequences do exist within other yeast genes; and fourthly, some of its reported sequences, encoding regions of the predicted protein related to protein kinase C, do not exist in any context in the yeast genome.CONCLUSIONS:
We conclude from these studies that the PKC2 gene is a composite construction of unrelated yeast and non-yeast sequences.
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Base de dados:
MEDLINE
Assunto principal:
Saccharomyces cerevisiae
/
Proteína Quinase C
/
Proteínas de Saccharomyces cerevisiae
/
Genes Fúngicos
Idioma:
En
Ano de publicação:
1994
Tipo de documento:
Article