Acquired tamoxifen resistance in human breast cancer and reduced intra-tumoral drug concentration.
Lancet
; 342(8886-8887): 1521-2, 1993.
Article
em En
| MEDLINE
| ID: mdl-7902904
ABSTRACT
Reduced intra-tumoral drug concentrations have been investigated as a mechanism of tamoxifen resistance in 51 patients with locally recurrent breast cancer. Serum tamoxifen was similar in patients with acquired and de-novo resistance, but intra-tumoral concentrations were significantly lower in patients with acquired resistance. Tumour oestrogen-receptor concentrations at relapse did not support the hypothesis that selective outgrowth of oestrogen-receptor-negative cells is a major mechanism for acquired tamoxifen resistance. Reduced intra-tumoral tamoxifen levels during prolonged therapy may be an important mechanism for acquired resistance in breast cancer.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Tamoxifeno
/
Neoplasias da Mama
/
Recidiva Local de Neoplasia
Idioma:
En
Ano de publicação:
1993
Tipo de documento:
Article