Molecular organization and evolution of mosquito genomes.

ABSTRACT

Given the importance of mosquitoes as disease vectors, relatively little is known about the molecular organization and evolution of mosquito genomes as compared to other insects such as fruit flies. The advances in recombinant DNA technology and the possibility that mosquito populations could be controlled and genetically manipulated using such technology has stimulated considerable research during the last few years in the areas of genome organization and evolution, genome mapping, endogenous transposable elements, and mapping and characterization of genes conferring susceptibility to different parasites and pathogens. This review summarizes research currently underway in our laboratory and elsewhere in these areas.