[Lipid infusion in multiple trauma intensive care patients in the early phase of treatment]. / Fettinfusion bei polytraumatisierten Intensivpatienten in der Frühphase der Behandlung.
Infusionsther Transfusionsmed
; 21(3): 150-8, 1994 Jun.
Article
em De
| MEDLINE
| ID: mdl-7919902
ABSTRACT
OBJECTIVES:
To study the metabolic effects of a high-dose fat infusion application in the early phase of total parenteral nutrition (TPN) after major trauma.DESIGN:
Prospective study in male patients after major trauma.SETTING:
Intensive care unit of the University Clinic. PATIENTS 21 male, mechanically ventilated patients after major trauma.INTERVENTIONS:
Infusion of Elolipid 20% (Fa. Leopold, Graz, Austria), starting on the 3rd day after ICU admission (0.075 g/kg body weight/h) in 8 h. The dose was increased on the 5th day (0.125 g/kg BW/h) and on the 7th day (0.15 g/kg BW/h).RESULTS:
There was a pathologic rise in serum triglycerides on days 3, 5 and 7 during the infusion period. A serious diabetic metabolic state was shown on the 3rd day. No significant changes in urea production rate could be demonstrated after the high-dose fat infusion.CONCLUSIONS:
The reason for the decreased fat elimination in patients after major trauma after high-dose fat infusion (8 h) remains unclear (fat clearance or fat oxidation failure). Therefore the fat infusion should be started after normalization of the blood glucose level. Thus the fat infusion should be given continuously over 24 h to avoid serious metabolic complications.
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Base de dados:
MEDLINE
Assunto principal:
Triglicerídeos
/
Traumatismo Múltiplo
/
Nutrição Parenteral Total
/
Emulsões Gordurosas Intravenosas
Idioma:
De
Ano de publicação:
1994
Tipo de documento:
Article