Degradation and disposal of some enzyme inhibitors. Scientific note.
Appl Biochem Biotechnol
; 48(2): 57-9, 1994 Aug.
Article
em En
| MEDLINE
| ID: mdl-7944352
ABSTRACT
Five enzyme inhibitors (phenylmethylsulfonyl fluoride, 4-amidinophenylmethanesulfonyl fluoride, 4-(2-aminoethyl)benzenesulfonyl fluoride, N alpha-p-tosyl-L-lysine chloromethyl ketone, and N-tosyl-L-phenylalanine chloromethyl ketone) in buffer, DMSO, or stock solutions were completely degraded by adding 1M NaOH and the final reaction mixtures were not mutagenic. The stability of these compounds decreased as the pH increased.
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Base de dados:
MEDLINE
Assunto principal:
Inibidores Enzimáticos
Idioma:
En
Ano de publicação:
1994
Tipo de documento:
Article