Secreted forms of beta-amyloid precursor protein protect against ischemic brain injury.
J Neurochem
; 63(2): 781-4, 1994 Aug.
Article
em En
| MEDLINE
| ID: mdl-8035204
ABSTRACT
The beta-amyloid precursor protein (beta APP) is the source of the amyloid beta-peptide that accumulates in the brain in Alzheimer's disease. A major processing pathway for beta APP involves an enzymatic cleavage within the amyloid beta-peptide sequence that liberates secreted forms of beta APP (APPss) into the extracellular milieu. We now report that postischemic administration of these APPss intracerebroventricularly protects neurons in the CA1 region of rat hippocampus against ischemic injury. Treatment with APPs695 or APPs751 resulted in increased neuronal survival, and the surviving cells were functional as demonstrated by their ability to synthesize protein. These data provide direct evidence for a neuroprotective action of APPss in vivo.
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Base de dados:
MEDLINE
Assunto principal:
Encéfalo
/
Ataque Isquêmico Transitório
/
Precursor de Proteína beta-Amiloide
/
Neurônios
Idioma:
En
Ano de publicação:
1994
Tipo de documento:
Article