Chromosomal aberrations in two adrenocortical tumors, one with a rearrangement at 11p15.
Cancer Genet Cytogenet
; 75(2): 111-6, 1994 Jul 15.
Article
em En
| MEDLINE
| ID: mdl-8055473
ABSTRACT
Adrenocortical tumors are detected with increasing frequency, but symptomatic cases with excessive hormone production are rare. We investigated cytogenetically one benign aldosterone-producing tumor (Conn Syndrome)(case 1) and one malignant cortisol-producing tumor (Cushing Syndrome)(case 2). Radioimmunoassay of cell culture supernatant of case 2 detected cortisol secretion during 2 months in culture. Flow cytometry of spill-out cells from case 2 showed a bimodal pattern (DNA Index 1.0, 1.4). Case 1 revealed a marker chromosome in 4/25 cells analyzed; the marker was a long acrocentric partially derived from chromosome 2,der(2q). In case 2, a cytogenetic harvest was achieved after prolonged culture time (6 weeks) and a marker chromosome, add(11)(p15), was detected in 16/22 cells. A breakpoint of 11p13, as well as loss of heterozygosity of alleles on 11p15, has been reported in the literature for other malignant adrenocortical cancers.
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Base de dados:
MEDLINE
Assunto principal:
Cromossomos Humanos Par 11
/
Aberrações Cromossômicas
/
Neoplasias do Córtex Suprarrenal
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Síndrome de Cushing
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Hiperaldosteronismo
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Síndromes Endócrinas Paraneoplásicas
Idioma:
En
Ano de publicação:
1994
Tipo de documento:
Article