[The modifying influence of thermal injury on the postradiation changes in the biochemical and functional activities of peritoneal macrophages]. / Modifitsiruiushchee vliianie termicheskoi travmy na postradiatsionnye izmeneniia biokhimicheskoi i funktsional'noi aktivnosti peritoneal'nykh makrofagov.

ABSTRACT

The effect of thermal injury on radiation-induced (3-7 Gy) changes in quantitative and qualitative composition, biochemical and functional activity of the peritoneal macrophages was studied. The reduce of peritoneal cells total number and alterations of their qualitative composition were conditioned by radiation component of combined radiation end thermal injury (CRTJ). The enzymes' activity and the protein content in macrophages were the most enhanced 7-9 days after CRTJ as compared with the effect of radiation per se. The early and the most pronounced luminol- and lucigenin-enhanced chemiluminescence increase in zymosan stimulated macrophages was conditioned by thermal component. The mechanisms of increase in the macrophages functional activity induced by radiation end CRTJ are discussed.