Erosive rheumatoid factor negative and positive rheumatoid arthritis are immunogenetically similar.
J Rheumatol
; 21(2): 194-6, 1994 Feb.
Article
em En
| MEDLINE
| ID: mdl-8182623
ABSTRACT
OBJECTIVE:
The relationship between rheumatoid factor positive (RF+) and rheumatoid factor negative (RF-) rheumatoid arthritis (RA) is controversial. We sought to determine whether the HLA genes conferring susceptibility for erosive RF+RA are also prevalent in patients with erosive RF-RA.METHODS:
DNA-based HLA typing for DRB1, DQB1, and DPB1 was performed on 16 consistently RF--patients with erosive RA.RESULTS:
Thirteen of 16 (81%) RF-RA patients had the HLA susceptibility genes DRB1 *0401, *0404, or *0101, which are associated with RF+RA, as compared to 46% of normal controls (p = 0.017). By contrast, no associations with HLA-DQB1 and HLA-DPB1 alleles were apparent.CONCLUSION:
Specific HLA susceptibility alleles are prevalent in patients with erosive RA, regardless of RF status, suggesting a similar immunogenetic basis for RA in these patients.
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Base de dados:
MEDLINE
Assunto principal:
Artrite Reumatoide
/
Fator Reumatoide
/
Antígenos HLA-D
Idioma:
En
Ano de publicação:
1994
Tipo de documento:
Article