Proton MR spectroscopy in patients with seizure disorders.
AJNR Am J Neuroradiol
; 15(2): 373-84, 1994 Feb.
Article
em En
| MEDLINE
| ID: mdl-8192088
ABSTRACT
PURPOSE:
To evaluate the ability of proton MR spectroscopy to detect metabolic abnormalities in the seizure focus of humans with epilepsy.METHODS:
Single-voxel MR spectroscopy and MR imaging was performed in a group of 13 patients with a variety of seizure disorders and in the temporal lobes of 14 healthy volunteers. Signals from choline, creatine, N-acetyl-L-aspartate, and lactate were quantitated in both the epileptogenic focus and the contralateral brain region.RESULTS:
In normal temporal lobe, concentrations of choline, creatine, and N-acetyl-L-aspartate were 2.0 +/- 0.7, 7.8 +/- 1.9, and 11.0 +/- 2.1 mumol/g wet weight, respectively, with no detectable lactate. In all patients, a reduction in the N-acetyl-L-aspartate signal was observed in the electrically defined (scalp electroencephalogram) seizure focus compared with the mirror-image contralateral side. Lactate was elevated only in patients who had seizures during or immediately before the MR examination. Seven of 13 patients studied had normal MR examinations.CONCLUSIONS:
Proton spectroscopy demonstrates alterations in N-acetyl-L-aspartate and lactate levels that can be used to locate the epileptogenic focus and may be a useful adjunctive diagnostic technique for the evaluation of patients with seizures who are eligible for resective surgery.
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Base de dados:
MEDLINE
Assunto principal:
Encéfalo
/
Espectroscopia de Ressonância Magnética
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Metabolismo Energético
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Epilepsia
Idioma:
En
Ano de publicação:
1994
Tipo de documento:
Article