Subretinal space and vitreous cavity as immunologically privileged sites for retinal allografts.
Invest Ophthalmol Vis Sci
; 34(12): 3347-54, 1993 Nov.
Article
em En
| MEDLINE
| ID: mdl-8225870
ABSTRACT
PURPOSE:
Because immune rejection is likely to be a major barrier to successful retinal transplantation, it is important to determine whether immune privilege for allogeneic retinal grafts is a feature of the subretinal space and vitreous cavity.METHODS:
Newborn neural retinas of C57BL/6 mice were implanted into the subretinal space, vitreous cavity, or subconjunctival space of eyes of adult BALB/c (disparate from C57BL/6 at major and minor histocompatibility loci). At postimplantation day 12, the recipients were evaluated for donor-specific delayed hypersensitivity and examined clinically and histologically for evidence of rejection.RESULTS:
Newborn neural retinal allografts in the subconjunctival space were destroyed by postimplantation day 12 and these recipients displayed intense donor-specific delayed hypersensitivity. By contrast, grafts in the subretinal space and vitreous cavity at postimplantation day 12 were found to be well differentiated and with no evidence of inflammation; these recipients failed to display donor-specific delayed hypersensitivity. Moreover, their spleens contained regulatory T cells that suppressed donor-specific delayed hypersensitivity in naive syngeneic recipients.CONCLUSIONS:
Allogeneic newborn neural retinal grafts implanted in the subretinal space and vitreous cavity experience immune privilege and induce deviant immune responses resembling anterior chamber associated immune deviation.
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Base de dados:
MEDLINE
Assunto principal:
Retina
/
Corpo Vítreo
Idioma:
En
Ano de publicação:
1993
Tipo de documento:
Article