Interaction of clavulanate with class C beta-lactamases.
FEBS Lett
; 334(3): 269-71, 1993 Nov 22.
Article
em En
| MEDLINE
| ID: mdl-8243630
ABSTRACT
The interactions between clavulanate and three class C enzymes have been studied in detail. In all cases, the reactions followed branched pathways where 25-150 turnovers occurred before inactivation was completed. Reactivation rates were quite low. The poor efficiency of clavulanate as a class C inactivator appeared to rest upon a very slow acylation of the protein, and of a relatively high turnover rate.
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Base de dados:
MEDLINE
Assunto principal:
Ácidos Clavulânicos
/
Inibidores de beta-Lactamases
Idioma:
En
Ano de publicação:
1993
Tipo de documento:
Article