Infection and morbidity in patients with tuberculosis in Nairobi, Kenya.
AIDS
; 7(11): 1469-74, 1993 Nov.
Article
em En
| MEDLINE
| ID: mdl-8280413
ABSTRACT
PIP: Tuberculosis (TB) is a common complication of HIV in Africa. A 1988-89 study further confirmed that considerable morbidity and mortality from acute bacterial infection occurred in HIV patients. It has also been found that anti-TB therapy seems to be as effective in HIV-positive as in HIV-negative TB patients. This paper reports on the level and nature of infectious morbidity suffered by HIV-positive patients receiving treatment for TB. The assessment is based upon a sample of inpatients and outpatients at the Infectious Diseases Hospital in Nairobi. Patients were aged 15 years and older, with a TB diagnosis presenting with 1 or more of a series of clinical features. 642 morbid events were seen in 398 patients: 235 HIV-positive patients had 438 event and 163 HIV-negative patients had 204 events. 18% of the HIV-positive patients versus 6% of the HIV-negative patients were bacteremic. Salmonella typhimurium and Streptococcus pneumoniae were most commonly isolated from sera, while fecal specimens were obtained more commonly from HIV-positive patients and often contained bacterial pathogens. The authors conclude that many causes of morbidity in patients with TB and HIV are not due to TB or anti-TB therapy and will not be identified without microbiological investigation. These results suggest that even with effective anti-TB chemotherapy HIV-positive patients will remain or become unwell.
Palavras-chave
Africa; Africa South Of The Sahara; Clinical Research; Demographic Factors; Developing Countries; Diseases; Eastern Africa; English Speaking Africa; Examinations And Diagnoses; Hiv Infections; Infections; Kenya; Laboratory Examinations And Diagnoses; Morbidity; Physical Examinations And Diagnoses; Population; Population Characteristics; Research Methodology; Research Report; Tuberculosis; Urban Population; Viral Diseases
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Base de dados:
MEDLINE
Assunto principal:
Tuberculose
/
Infecções por HIV
Idioma:
En
Ano de publicação:
1993
Tipo de documento:
Article