Preferential survival of mice expressing the Qa-2 antigen.
J Reprod Fertil
; 99(1): 145-7, 1993 Sep.
Article
em En
| MEDLINE
| ID: mdl-8283431
ABSTRACT
The Ped gene, a gene that influences the rate of embryonic cleavage division, birth weight, litter size and weaning weight, is at least partially encoded by gene(s) that specify the Qa-2 antigen. Two congenic strains of mice, B6.K1 (Qa-2 negative) and B6.K2 (Qa-2 positive), which differ only at the Q region of the mouse major histocompatibility complex (MHC), were tested for the effect of the presence or absence of Qa-2 antigen on litter size, duration of gestation and embryo survival. It was confirmed that B6.K1 (Qa-2 negative) mice have smaller litters than do B6.K2 (Qa-2 positive) mice. In addition, the duration of gestation for the B6.K1 mice was found to be longer than the duration of gestation for the B6.K2 mice. Finally, a comparison of the relative survival of Qa-2-positive and Qa-2-negative mice in a single uterine environment showed the preferential survival of mice expressing the Qa-2 antigen. Thus, the presence of Qa-2 antigen appears to be advantageous for reproductive success.
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Base de dados:
MEDLINE
Assunto principal:
Antígenos de Histocompatibilidade Classe I
/
Antígenos H-2
/
Viabilidade Fetal
/
Camundongos Endogâmicos
Idioma:
En
Ano de publicação:
1993
Tipo de documento:
Article