Absence of MDM-2 gene amplification in experimentally induced tumors regardless of p53 status.
Mol Carcinog
; 9(1): 40-5, 1994 Jan.
Article
em En
| MEDLINE
| ID: mdl-8297484
ABSTRACT
To assess the generality of the hypothesis that murine double-minute-2 (MDM-2) gene amplification complements the absence of p53 mutation during tumor development, we analyzed 143 murine tumors induced by a variety of carcinogenic agents in two different mouse strains. Only three of 143 tumors showed p53 genetic alterations and none showed MDM-2 amplification, indicating the existence of alternative pathways that permit tumor cells to bypass p53-MDM-2 control.
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Base de dados:
MEDLINE
Assunto principal:
Proteínas Nucleares
/
Amplificação de Genes
/
Genes p53
/
Proteínas Proto-Oncogênicas
/
Proteínas de Neoplasias
/
Neoplasias Experimentais
Idioma:
En
Ano de publicação:
1994
Tipo de documento:
Article