[Phosphorimetric analysis of carbaindoline].
Yao Xue Xue Bao
; 28(2): 140-5, 1993.
Article
em Zh
| MEDLINE
| ID: mdl-8328284
ABSTRACT
Carbaindoline possesses strong phosphorescence with excitation at 304 mm and emission at 434 nm in water at 77 K. The phosphorescence is stronger in alkaline media than in acid media. Kl enhances the phosphorescence of carbaindoline but shortens the life time. The heavy cations Cu2+, Fe3+, Pb2+, Tl3+, Zn2+, and molybdate do not enhance the phosphorescence, but some of them, Cu2+ and Fe3+, have quenching effect on carbaindoline phosphorescence. The phosphorescence of nine carbaindoline analogues was studied. After oxidation of > CH2 at position 2 to > C = O, the phosphorescence decreased significantly. The phosphorimetric method for analysis of carbaindoline was established with a detection limit of 5 ng/ml. Ten minutes after ip administration of carbaindoline 0.1 mg/kg to mice, the blood drug concentration was found to be 149 +/- 27 ng/ml.
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Base de dados:
MEDLINE
Assunto principal:
Carbamatos
/
Inibidores da Colinesterase
/
Indóis
Idioma:
Zh
Ano de publicação:
1993
Tipo de documento:
Article