Use of viscosigens to stabilize vitamin B12 solutions against photolysis.
J Pharm Sci
; 82(6): 641-3, 1993 Jun.
Article
em En
| MEDLINE
| ID: mdl-8331540
ABSTRACT
Glycerol stabilizes cyanocob(III)alamin (vitamin B12) against anaerobic photolysis by a high-intensity UV light source or a low-intensity fluorescent light source. The likely mechanism for stabilization by viscosigens is a decrease in diffusion and an enhancement of radical-pair recombination. Glycerol (25% or greater) stabilizes therapeutic doses of vitamin B12 in single-dose Tubex injection vials against adventitious photolysis by fluorescent light.
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Base de dados:
MEDLINE
Assunto principal:
Vitamina B 12
/
Ficoll
/
Glicerol
Idioma:
En
Ano de publicação:
1993
Tipo de documento:
Article