Glycoprotein 2 of zymogen granule membranes shares immunological cross-reactivity and sequence similarity with phospholipase A2.
Biochem Biophys Res Commun
; 194(3): 1167-74, 1993 Aug 16.
Article
em En
| MEDLINE
| ID: mdl-8352773
ABSTRACT
Glycoprotein 2 (GP2), the major protein of rat pancreatic zymogen granule membranes (ZGMs), cross-reacted with an antiserum against porcine secretory phospholipase A2 (sPLA2). Amino acid sequence comparison showed 45% similarity and 23% identity between porcine PLA2 and the C-terminal portion of GP2. An antiserum to intestinal brush border Ca(2+)-independent PLA2 (bbPLA2) also recognized GP2. The antigenic and sequence similarities between GP2, sPLA2, and bbPLA2 imply that the role of GP2 in cellular function is associated with phospholipid binding and/or hydrolysis.
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Base de dados:
MEDLINE
Assunto principal:
Fosfolipases A
/
Glicoproteínas de Membrana
/
Grânulos Citoplasmáticos
/
Membranas Intracelulares
Idioma:
En
Ano de publicação:
1993
Tipo de documento:
Article