Expression of synaptotagmin and syntaxin associated with N-type calcium channels in small cell lung cancer.
FEBS Lett
; 326(1-3): 135-9, 1993 Jul 12.
Article
em En
| MEDLINE
| ID: mdl-8391990
ABSTRACT
The presence of synaptic proteins involved in excitation/secretion coupling was examined in ten small cell lung cancer lines. N-Type calcium channels (omega-conotoxin receptors), synaptotagmin (p65) and syntaxin (HPC-1) were detected in eight. Co-immunoprecipitation experiments indicated that syntaxin can form a complex with synaptotagmin and calcium channels. The expression of synaptotagmin in small cell lung cancer may elicit an autoimmune response that reduces transmitter release at the nerve terminal.
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Base de dados:
MEDLINE
Assunto principal:
Proteínas de Ligação ao Cálcio
/
Glicoproteínas de Membrana
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Canais de Cálcio
/
Carcinoma de Células Pequenas
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Neoplasias Pulmonares
/
Antígenos de Superfície
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Proteínas do Tecido Nervoso
Idioma:
En
Ano de publicação:
1993
Tipo de documento:
Article