Human colonic intraepithelial lymphocytes suppress in vitro immunoglobulin synthesis by autologous peripheral blood lymphocytes and lamina propria lymphocytes.
Gut
; 34(2): 257-63, 1993 Feb.
Article
em En
| MEDLINE
| ID: mdl-8432483
ABSTRACT
Human colonic intraepithelial lymphocytes have been shown to suppress the proliferation of autologous lamina propria lymphocytes and allogeneic peripheral blood mononuclear cells. This study has shown that, in vitro, intraepithelial lymphocytes suppress IgA and total immunoglobulin synthesis (but not IgG or IgM production) by autologous peripheral blood and lamina propria lymphocytes. This down regulation of IgA production is mediated by a soluble factor secreted by the intraepithelial lymphocytes. There is no difference in immunoglobulin down regulation by intraepithelial lymphocytes of control subjects and patients with inflammatory bowel disease.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Imunoglobulinas
/
Linfócitos T
/
Doenças Inflamatórias Intestinais
/
Colo
/
Tolerância Imunológica
Idioma:
En
Ano de publicação:
1993
Tipo de documento:
Article