Cytotoxic and cytostatic activity of copper(II) complexes. Importance of the speciation for the correct interpretation of the in vitro biological results.
J Inorg Biochem
; 50(1): 31-45, 1993 Apr 01.
Article
em En
| MEDLINE
| ID: mdl-8473882
ABSTRACT
The cytotoxicity of some copper(II) compounds against the mouse cancer cell line B16, murine L929, human KB cells, and fibroblasts was investigated. All the copper(II) systems tested were shown to have pronounced toxicity against transformed cells and a cytostatic effect against untransformed cells, i.e., human fibroblasts. A careful speciation of the actual in vitro conditions reveals that copper(II) is essentially present as mixed complexes formed with the amino acids of the culture medium, [Cu(glutamine)(histidine)] being the main species. It was found that the cytotoxic activity is related to the amount of copper(II) contained in the tested compounds.
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Base de dados:
MEDLINE
Assunto principal:
Cobre
/
Antineoplásicos
Idioma:
En
Ano de publicação:
1993
Tipo de documento:
Article