Synergists for retinoid in cellular differentiation of human promyelocytic leukemia cells HL-60.
Chem Pharm Bull (Tokyo)
; 43(10): 1827-9, 1995 Oct.
Article
em En
| MEDLINE
| ID: mdl-8536354
ABSTRACT
4-[5H-2,3-(2,5-Dimethyl-2,5-hexano)-5-methyldibenzo[b, e]diazepin-11-yl]benzoic acid (4) enhanced the differentiation-inducing activity of retinoic acid (1) and of a synthetic retinoid Am80 (2) toward human promyelocytic leukemia cells HL-60, although 4 alone did not induce differentiation. The synergistic effect of 4 on the activities of retinoids was also seen in suppression of proliferation of HL-60 cells.
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Base de dados:
MEDLINE
Assunto principal:
Tretinoína
/
Leucemia Promielocítica Aguda
/
Diferenciação Celular
Idioma:
En
Ano de publicação:
1995
Tipo de documento:
Article