Aerosolized beta 2-agonists do not induce bronchial hyperreactivity in healthy adults.
Ann Pharmacother
; 29(9): 848-51, 1995 Sep.
Article
em En
| MEDLINE
| ID: mdl-8547730
ABSTRACT
OBJECTIVE:
To determine whether regular administration of beta 2-agonists could induce bronchial hyperreactivity in nonasthmatic volunteers.DESIGN:
A prospective, randomized, double-blind, placebo-controlled, crossover clinical trial of 2 weeks therapy with a 2-week washout period between each treatment period. Treatments were albuterol or matching placebo as 2 inhalations 4 times daily.SUBJECTS:
Ten healthy, nonsmoking women 27-37 years old.SETTING:
General clinical research center of a tertiary care university hospital. MAIN OUTCOMEMEASURES:
Baseline spirometry and methacholine bronchoprovocation studies were performed immediately prior to, 12 hours following, and 1 and 2 weeks following each treatment period.RESULTS:
No change was detected in either baseline spirometry or methacholine responsiveness.CONCLUSIONS:
This suggests that if beta 2-agonists induce a rebound bronchial hyperreactivity, it is not the result of the production of tolerance or a direct effect on bronchial smooth muscle.
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Base de dados:
MEDLINE
Assunto principal:
Hiper-Reatividade Brônquica
/
Agonistas Adrenérgicos beta
/
Agonistas de Receptores Adrenérgicos beta 2
Idioma:
En
Ano de publicação:
1995
Tipo de documento:
Article