[Studies on colonic mucus release--II. Damaged colon mucosa].

ABSTRACT

The release of goblet cell mucus (GCM) was examined in immune reaction-system of colonic mucosa of rats (SD rats). We previously reported that in the immune reaction of normal colon of rats, the discharge of colonic GCM was not increased by intrarectal instillation (challenge) of several test-antigens after repeated immunization of single BSA antigen through rectal mucosa, and there was difference in local antigen-antibody reaction on the surface of normal mucosa between small intestine and colon. In the present study we investigated the release of colonic GCM in local antigen-antibody system in rats of damaged colon mucosa, who had repeated immunization of BSA after damage induction by intracolonic infusion of formalin. Consequently, the discharge of colonic GCM increased associated with local antigen-antibody reaction in animals after damage induction by formalin. It is suggested that when the mucosal barrier is disrupted, enhanced release of colonic GCM is occurred by the local immune reaction on the surface of colonic mucosa.