Increased cerebrospinal fluid pyruvate levels in Alzheimer's disease.
Neurosci Lett
; 199(3): 231-3, 1995 Oct 27.
Article
em En
| MEDLINE
| ID: mdl-8577405
ABSTRACT
Impaired energy metabolism is an early, predominant feature in Alzheimer's disease. In order to find out simple, reliable 'in vivo' markers for the clinical-biological typization of the disorder, we measured cerebrospinal fluid (CSF) glucose, lactate and pyruvate levels in patients suffering from dementia of Alzheimer type (DAT) and in healthy elderly controls. DAT group showed remarkably higher levels of pyruvate (P = 0.01), with no overlap with the values obtained in controls. CSF pyruvate levels were also significantly associated with the severity of dementia. Therefore, CSF pyruvate levels neatly separate DAT patients from controls, having also pathogenetic value.
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Base de dados:
MEDLINE
Assunto principal:
Piruvatos
/
Doença de Alzheimer
/
Lactatos
Idioma:
En
Ano de publicação:
1995
Tipo de documento:
Article