Ontogeny of two different benzodiazepine binding sites in the chick optic lobe.
Neuroreport
; 6(15): 2013-6, 1995 Oct 23.
Article
em En
| MEDLINE
| ID: mdl-8580430
ABSTRACT
The developmental time-course of type I and type II benzodiazepine receptors in the chick optic lobe was determined using a triazolopyridazine, CL 218872. At embryonic day 13 most of the binding sites corresponded to type II (98.23%), while type I represented only a minor proportion (1.77%). During development there was an increase in type I binding sites which reached 62.88% in adulthood, while type II binding sites decreased to 37.12%. These results demonstrate a differential ontogeny of two benzodiazepine receptor subtypes. Changes in the benzodiazepine binding population may account for the variability in the GABA-benzodiazepine receptor interaction during chick optic lobe development.
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Base de dados:
MEDLINE
Assunto principal:
Teto do Mesencéfalo
/
Receptores de GABA-A
Idioma:
En
Ano de publicação:
1995
Tipo de documento:
Article