[Cardiac gene expression after brief coronary occlusion]. / Kardiale Genexpression nach kurzen Koronarverschläussen.
Z Kardiol
; 84 Suppl 4: 159-65, 1995.
Article
em De
| MEDLINE
| ID: mdl-8585269
ABSTRACT
In the pig short coronary occlusions induce molecular damage on the protein level in the myocardium, which elicit repair mechanisms by increased transcription and translation, including the activation of potential transcription factors (protooncogenes), genes involved in repair processes (heat shock genes) or calcium-binding genes. Additionally, some growth factors like insulin-like growth factor II show increased transcription in accordance with their function as trophic factors for reversibly injured myocardium. Changes in mRNA levels mostly are due to increased transcription rates and rarely due to prolonged half-life of the mRNA. However, at present our data do not allow us to conclude which genes are causative for myocardial stunning and/or ischemic preconditioning.
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Base de dados:
MEDLINE
Assunto principal:
Fatores de Transcrição
/
Traumatismo por Reperfusão Miocárdica
/
Substâncias de Crescimento
/
Proteínas de Choque Térmico
/
Infarto do Miocárdio
Idioma:
De
Ano de publicação:
1995
Tipo de documento:
Article