Recurrent miscarriage is associated with increased numbers of CD5/20 positive lymphocytes and an increased incidence of thyroid antibodies.
Eur J Endocrinol
; 134(1): 84-6, 1996 Jan.
Article
em En
| MEDLINE
| ID: mdl-8590962
ABSTRACT
PIP: The aim of this study was to determine whether recurrent miscarriage (three or more miscarriages, no live children) was associated with an increased incidence of autoantibodies. Five groups were enrolled into the study: healthy nonpregnant women, healthy first-trimester pregnant women, women suffering spontaneous abortion, those undergoing termination of pregnancy, and those with a previous history of miscarriage. The number of total B cells and the numbers of the antibody-producing B cell subset CD5+/20+ were determined for each group. Samples were tested for anticardiolipin antibodies, antinuclear antibodies, and thyroid microsomal and thyroglobulin antibodies. The results showed that compared to normal pregnancy or spontaneous abortion, recurrent miscarriage was associated with a significant increase in the number of CD5+/20+ cells (0.8 +or- 0.3 vs. 0.5 +or- 0.1 vs. 1.1 +or- 0.3 x 108/L: p 0.001). These women were also found to have a higher incidence of thyroid antibodies, with 4 of the 11 patients being positive for thyroid microsomal antibodies. These results suggest that there may be an association between autoimmunity and recurrent miscarriage.
Palavras-chave
Abortion, Spontaneous; Antibodies; Autoantibodies; Autoimmune Response; Biology; Demographic Factors; Developed Countries; Diseases; Europe; Examinations And Diagnoses; Immunity; Immunologic Factors; Laboratory Examinations And Diagnoses; Northern Europe; Physiology; Population; Population Characteristics; Pregnancy Complications; Pregnant Women; Research Report; United Kingdom
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Base de dados:
MEDLINE
Assunto principal:
Autoanticorpos
/
Linfócitos B
/
Aborto Habitual
/
Antígenos CD5
/
Antígenos CD20
Idioma:
En
Ano de publicação:
1996
Tipo de documento:
Article