Pharmacology and toxicology of phosphorothioate oligonucleotides in the mouse, rat, monkey and man.
Toxicol Lett
; 82-83: 425-30, 1995 Dec.
Article
em En
| MEDLINE
| ID: mdl-8597088
ABSTRACT
Phosphorothioate oligonucleotides (PS-ODN) designed to temporarily modulate selected gene expression have made the journey from bench top to beside in a remarkably short period of time. A PS-ODN with sequence complementary to the p53 mRNA was administered to mice (4 mg/kg subcutaneously), rats (3-300 mg/kg intravenously), monkeys (intravenous infusions for up to 15 days) and humans (up to 0.25 mg/kg/h intravenous infusions for 10 days). These studies demonstrate the PS-ODN provides feasible pharmacokinetic parameters and minimal toxicity.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Tionucleotídeos
/
Oligonucleotídeos Antissenso
Idioma:
En
Ano de publicação:
1995
Tipo de documento:
Article