HTLV-I and HTLV-II Tax: differences in induction of micronuclei in cells and transcriptional activation of viral LTRs.
Virology
; 217(1): 373-9, 1996 Mar 01.
Article
em En
| MEDLINE
| ID: mdl-8599225
ABSTRACT
Human T-cell leukemia virus (HTLV) types I and II are highly related viruses that differ in disease manifestations. HTLV-I has been linked unmistakably to adult T-cell leukemia-lymphoma. On the other hand, there is little evidence that prior infection with HTLV-II increases risk for lymphoproliferative disorders. Both viruses encode homologous transcriptional-activating proteins (respectively designated as Tax1 and Tax2) which have been suggested to be important mediators of viral pathogenesis. Previously, we reported that Tax1 is a potent inducer of micronuclei formation in cells. Here, we present evidence that Tax2 lacks micronuclei inductive ability. We contrast this phenotypic difference between Tax1 and Tax2 at the cellular level with their similarities at the molecular level in transcriptional activation.
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Base de dados:
MEDLINE
Assunto principal:
Sequências Repetitivas de Ácido Nucleico
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Vírus Linfotrópico T Tipo 1 Humano
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Vírus Linfotrópico T Tipo 2 Humano
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Ativação Transcricional
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Produtos do Gene tax
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Micronúcleos com Defeito Cromossômico
Idioma:
En
Ano de publicação:
1996
Tipo de documento:
Article