The influence of multiple oral doses of zileuton on the steady-state pharmacokinetics of sulfasalazine and its metabolites, sulfapyridine and N-acetylsulfapyridine.
Clin Pharmacokinet
; 29 Suppl 2: 98-104, 1995.
Article
em En
| MEDLINE
| ID: mdl-8620678
ABSTRACT
The effects of zileuton (Abbott-64077) on the pharmacokinetics of sulfasalazine (SASP) and its metabolites, sulfapyridine (SP) and N-acetylsulfapyridine (ASP), were studied in a randomised double-blind placebo-controlled study enrolling 14 healthy male volunteers. All subjects received SASP 1 g every 12 hours for 8 days and zileuton 800mg or placebo administered twice daily from day 4 to day 8 inclusive. Coadministration of zileuton did not significantly affect the area under the plasma concentration-time curve, the maximum (Cmax) or minimum (Cmin) plasma concentration and the time to Cmax of SASP, SP or ASP. Likewise, zileuton did not modify the terminal elimination half-life of SASP. It is concluded that coadministration of zileuton 1.6 g/day has no significant effects on the pharmacokinetics of SASP 2 g/day or its metabolites, SP and ASP.
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Base de dados:
MEDLINE
Assunto principal:
Sulfassalazina
/
Inibidores de Lipoxigenase
/
Hidroxiureia
/
Anti-Infecciosos
/
Anti-Inflamatórios
Idioma:
En
Ano de publicação:
1995
Tipo de documento:
Article