Prevention of islet allograft rejection with engineered myoblasts expressing FasL in mice.
Science
; 273(5271): 109-12, 1996 Jul 05.
Article
em En
| MEDLINE
| ID: mdl-8658177
ABSTRACT
Allogeneic transplantation of islets of Langerhans was facilitated by the cotransplantation of syngeneic myoblasts genetically engineered to express the Fas ligand (FasL). Composite grafting of allogeneic islets with syngeneic myoblasts expressing FasL protected the islet graft from immune rejection and maintained normoglycemia for more than 80 days in mice with streptozotocin-induced diabetes. Graft survival was not prolonged with composite grafts of unmodified myoblasts or Fas-expressing myoblasts. Islet allografts transplanted separately from FasL-expressing myoblasts into the contralateral kidney were rejected, as were similarly transplanted third-party thyroid allografts. Thus, the FasL signal provided site- and immune-specific protection of islet allografts.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Glicoproteínas de Membrana
/
Transplante das Ilhotas Pancreáticas
/
Fibras Musculares Esqueléticas
/
Rejeição de Enxerto
Idioma:
En
Ano de publicação:
1996
Tipo de documento:
Article