Targeted radiotherapy of osteosarcoma using 153 Sm-EDTMP. A new promising approach.
Acta Oncol
; 35(3): 381-4, 1996.
Article
em En
| MEDLINE
| ID: mdl-8679270
ABSTRACT
We report a case where targeted radionuclide therapy using 153Sm-EDTMP gave substantial palliative effect. A 35-year-old male with a primary osteosarcoma located in the first lumbar vertebra relapsed with progressive back pain after conventional treatment modalities had failed. He became bedridden, and developed paraparesis and impaired bladder function. On a diagnostic bone-scan intense radioactivity was localized in the tumor. He therefore was given 153Sm-EDTMP treatment twice, 8 weeks apart, 35 and 32 MBq/kg body weight respectively. After a few days the pain was significantly relieved and by the second radionuclide treatment the pareses subsided. For six months he was able to be up and about without any neurological signs or detectable metastases. Eventually, however, he experienced increasing local pain, developed paraparesis, was re-operated but died 4 months later. The dramatic transient improvement observed in this case warrants further exploration using 153Sm-EDTMP as a boost technique, supplementary to conventional external radiotherapy.
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Base de dados:
MEDLINE
Assunto principal:
Compostos Organometálicos
/
Compostos Organofosforados
/
Radioisótopos
/
Samário
/
Neoplasias da Coluna Vertebral
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Osteossarcoma
/
Radioimunoterapia
/
Analgésicos não Narcóticos
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Vértebras Lombares
Idioma:
En
Ano de publicação:
1996
Tipo de documento:
Article