[Amplification of oncogene c-erb-B1 and cellular DNA content in squamous cell carcinoma of the head and neck]. / Amplificación del oncogén c-erbB1 y contenido celular de ADN en los carcinomas epidermoides de cabeza y cuello.
Acta Otorrinolaringol Esp
; 47(2): 97-103, 1996.
Article
em Es
| MEDLINE
| ID: mdl-8695214
Tumoral DNA content was studied by flow cytometry and PCR amplification of c-erbB1 in tissue samples from 31 patients with squamous cell carcinoma of the head and neck. Eighteen cases (58%) were aneuploid and 13 (42%) were diploid. Aneuploidy correlated with pharyngeal site and poorly differentiated tumors, but not with clinical stage or metastases. Six (19.3%) cases had c-erbB1 amplification, which correlated with tumor size, nodal metastasis, poor differentiation, and hypopharyngeal site. Only 20% of patients with amplification survived 30 months, compared with 64% of patients without amplification. None of the patients with aneuploidy and c-erbB1 amplification survived more than 15 months. To conclude, the measurement of cellular DNA content and c-erbB1 amplification seem to have prognostic value in squamous cell carcinoma of the head and neck.
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Base de dados:
MEDLINE
Assunto principal:
Orofaringe
/
Neoplasias Bucais
/
Carcinoma de Células Escamosas
/
Neoplasias Hipofaríngeas
/
Neoplasias Orofaríngeas
/
Amplificação de Genes
/
Receptores ErbB
/
Hipofaringe
/
Boca
Idioma:
Es
Ano de publicação:
1996
Tipo de documento:
Article