Urinary epitectin (MUC-1 glycoprotein) in the menstrual cycle and interstitial cystitis.
J Urol
; 156(3): 938-42, 1996 Sep.
Article
em En
| MEDLINE
| ID: mdl-8709368
ABSTRACT
PURPOSE:
We compared interstitial cystitis and control urine specimens for epitectin (MUC-1 glycoprotein), an epithelial mucin. MATERIALS ANDMETHODS:
Urinary epitectin was measured in 28 patients with interstitial cystitis and 26 healthy controls. Ten controls provided multiple urine samples to determine whether urinary epitectin changes with the menstrual cycle.RESULTS:
Epitectin levels were stable throughout the menstrual cycle. Interstitial cystitis cases had decreased urinary epitectin-to-creatinine ratios (mean 3.89 versus 6.38 micrograms./mg. creatinine for controls, p = 0.0035) and epitectin concentrations (mean 1.96 versus 4.30 micrograms./ml., respectively, p = 0.0005).CONCLUSIONS:
Decreased mean urinary epitectin levels may reflect a cause (epithelial mucin deficiency) or a consequence of interstitial cystitis.
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Base de dados:
MEDLINE
Assunto principal:
Mucina-1
/
Cistite Intersticial
/
Ciclo Menstrual
/
Proteínas de Neoplasias
Idioma:
En
Ano de publicação:
1996
Tipo de documento:
Article