A simplified technique for in vivo analysis of sister-chromatid exchanges using 5-bromodeoxyuridine tablets.
Cytogenet Cell Genet
; 18(4): 231-7, 1977.
Article
em En
| MEDLINE
| ID: mdl-872628
ABSTRACT
A small tablet of 5-bromodeoxyuridine (BrdU), implanted subcutaneously in a mouse, provides sustained release of base analog sufficient to effect substitution of DNA throughout an entire replication period. As illustrated by studies of mouse bone-marrow and spleen cells in the presence or absence of cyclophosphamide, this depot method of BrdU administration greatly simplifies in vivo analysis of sister-chromatid-exchange formation.
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Base de dados:
MEDLINE
Assunto principal:
Bromodesoxiuridina
/
Divisão Celular
/
Cromátides
Idioma:
En
Ano de publicação:
1977
Tipo de documento:
Article