Altered L-DOPA systems for blood pressure regulation in the lower brainstem of spontaneously hypertensive rats.
Hypertens Res
; 18(4): 267-77, 1995 Dec.
Article
em En
| MEDLINE
| ID: mdl-8747304
ABSTRACT
Recent findings have enhanced our understanding of the roles played by the L-DOPA system in the baroreceptor reflex and in blood pressure regulation in the lower brainstem. L-DOPA is probably a neurotransmitter of primary baroreceptor afferents terminating in depressor sites of the nucleus tractus solitarii (NTS). It also seems to be a neurotransmitter in depressor sites of the caudal ventrolateral medulla (CVLM) and in pressor sites of the rostral ventrolateral medulla (RVLM) of normotensive Wistar rats. We have explored whether or not presynaptic and postsynaptic functions of the L-DOPA system in these areas are altered to maintain hypertension in adult spontaneously hypertensive rats, as compared with age-matched Wistar Kyoto rats. In this review article, we survey the roles of the L-DOPA system in the baroreceptor reflex and in blood pressure regulation in the rat lower brainstem.
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Base de dados:
MEDLINE
Assunto principal:
Ratos Endogâmicos SHR
/
Tronco Encefálico
/
Levodopa
/
Hipertensão
Idioma:
En
Ano de publicação:
1995
Tipo de documento:
Article