[Nephrotic syndrome complicating treatment with interferon alpha]. / Syndrome néphrotique compliquant un traitement par interféron alpha.
Presse Med
; 25(23): 1066-8, 1996 Jun 29.
Article
em Fr
| MEDLINE
| ID: mdl-8760627
ABSTRACT
UNLABELLED We report two cases of nephrotic syndrome with minimal glomerular change complicating alpha-interferon therapy. CASE REPORTS The first patient was a 60-year-old man with Waldenström's disease who was given 1 million units of alpha-interferon three times a week for 22 months. Acute renal failure developed when a second protocol was started. Renal biopsy revealed intraglomerular deposits and no cellular proliferation. Total remission could not be achieved with corticosteroids. The second case was a 46-year-old man given high dose alpha-interferon (15 million units 3 times a week) for lymph node metastasis of a malignant melanoma. A nephrotic syndrome without renal failure developed during the third month of treatment. Minimal glomerular involvement was seen. Symptomatic treatment led to resolution of the nephrotic syndrome. DISCUSSION:
Nine other cases of nephrotic syndrome complicating alpha-interferon therapy have been reported in the literature.
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Base de dados:
MEDLINE
Assunto principal:
Interferon-alfa
/
Síndrome Nefrótica
/
Antineoplásicos
Idioma:
Fr
Ano de publicação:
1996
Tipo de documento:
Article