Thallium-201 scintigraphy to assess effect of chemotherapy in osteosarcoma.
J Nucl Med
; 37(9): 1444-8, 1996 Sep.
Article
em En
| MEDLINE
| ID: mdl-8790189
ABSTRACT
UNLABELLED Imaging results in patients with high-grade osteosarcoma of the extremities were reviewed to determine whether scintigraphic appearance correlated with histologic response to preoperative chemotherapy. METHODS:
Histologically, the percent tumor necrosis in specimens from 30 patients were classified into three grades grade 1 = necrosis less than 60%, grade 2 = 60%-89% necrosis and grade 3 = diffuse necrosis greater than 90% based upon whole transverse sections. Scintigraphically, we analyzed 201TI uptake before and after preoperative chemotherapy. The changes in the tumor-to-background ratio were defined by an alteration ratio.RESULTS:
Of the 11 patients with a grade 1 response, the ratio showed -67.1% +/- 45.4% (mean +/- s.d.). Of the 9 patients with a grade 2 response, the ratio showed 37.9% +/- 29.9% of the 10 patients with a grade 3 response the ratio showed 105.5% +/- 12.4%. The ratios correlated well with the histologic grades (p < 0.0001; analysis of variance).CONCLUSION:
Thallium-201 scintigraphy accurately assesses the effect of chemotherapy on osteosarcoma.
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Base de dados:
MEDLINE
Assunto principal:
Neoplasias Ósseas
/
Radioisótopos de Tálio
/
Protocolos de Quimioterapia Combinada Antineoplásica
/
Osteossarcoma
Idioma:
En
Ano de publicação:
1996
Tipo de documento:
Article